Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
AlphaFold solved protein structure prediction but left protein dynamics and biology unsolved
Google DeepMind's Pushmeet Kohli and Biohub's Sal Candido argue that AlphaFold's breakthrough was only the beginning, as static structure prediction leaves protein dynamics, disorder, and whole-cell modeling unsolved. They contend that scaling compute and data alone won't crack biology — the right scaling laws and high-quality data matter more than raw model size. The conversation points toward a new generation of AI models needed to simulate living systems and potentially deliver 10x–100x acceleration in drug discovery.